In order for you to play A Story About My Uncle on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
OS X 10.7
Processor (CPU):
Intel Core 2 Duo, AMD Athlon X2, or equal at 1.6GHz or better
Memory (RAM):
2 GB RAM
Graphics Card:
Intel HD Graphics 4000
Storage:
2 GB available space