Om Serious Sam HD: The Second Encounter op Windows te kunnen spelen met minimale grafische instellingen, moet uw computer aan de volgende eisen voldoen
OS *:
Windows XP w/SP1 or newer
Processor:
Intel Pentium 4 3+ Ghz or AMD Athlon64 3500+
Memory:
1 GB for Windows XP or 2 GB for Windows Vista
Hard Drive:
2.2 GB free space
Graphics:
nVidia GeForce 7600, ATI Radeon X1600 (Shader Model 3.0 Required)
Sound:
Direct X 9.0c compatible sound card
DirectX®:
DirectX 9.0c August 2009 Edition or newer