In order for you to play Sherlock Holmes Consulting Detective: The Case of the Mystified Murderess on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
High Sierra 10.13+ (Intel editor) Big Sur 11.0 (Apple silicon Editor)
Processor (CPU):
X64 architecture with SSE2 instruction set support (Intel processors) Apple M1 or above (Apple silicon-based processors)
Memory (RAM):
512 MB RAM
Graphics Card:
Metal-capable Intel and AMD GPUs