In order for you to play Moonlighter on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
10.6
Processor (CPU):
Intel(R) Core(TM)2 Quad 2.7 Ghz, AMD Phenom(TM)II X4 3 Ghz
Memory (RAM):
4 GB RAM
Graphics Card:
GeForce GTX 260, Radeon HD 5770, 1024 MB, Shader Model 3.0
Storage:
4 GB available space
Sound Card:
Integrated