In order for you to play Clicker Heroes 2 on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
Mac OS X v10.6, and above
Processor (CPU):
Intel® Core™ Duo 1.83GHz or faster processor
Memory (RAM):
2 GB RAM
Graphics Card:
2008 or newer graphics card.
Storage:
3 GB available space
Sound Card:
Any sound card.