In order for you to play Sanctum on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
OS X 10.6.3
Processor (CPU):
1.6 GHz Dual Core Processor
Memory (RAM):
2 GB RAM
Hard Disk Space:
2 GB Free Space
Video Card:
Open GL 3.3, Shader Model 3, 256 MB VRAM