In order for you to play Anodyne 2: Return to Dust on macOS with minimal graphics settings, your computer must meet the following requirements
Operating System:
10.12 or higher. Earlier versions are NOT supported.
Processor (CPU):
Dual-core 2.5 GHz
Memory (RAM):
4 GB RAM
Graphics Card:
GeForce 610M Equivalent
Storage:
500 MB available space
Sound Card:
Any